The Roles of Invariant NKT Cells in Bowel Immunity — Suppression of Tumor Progression and Rejection of Intestinal Transplants
نویسندگان
چکیده
The roles of natural killer (NK)T cells in intestinal immunity have not been sufficiently investigated. The bowel possesses its own unique mucosal immune system, the gut-associated lymphoepithelial tract (GALT). In this review, we focused on CD1d-independent invariant type NKT (iNKT) cells as modulators of GALT. iNKT cells have a restricted invariant T-cell receptor (TCR) Vα24 chain paired with Vβ11 chain. In addition to T helper (Th)1 cytokines, such as IFN-γ, iNKT cells can produce anti-inflammatory Th2 cytokines, such as interleukin (IL)-4.
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